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Sophia Jagiellon (Polish: Zofia Jagiellonka; Lithuanian: Sofija Jogailaitė; 6 May 1464 – 5 October 1512) was a princess of the Kingdom of Poland and of the Grand Duchy of Lithuania, member of the Jagiellonian dynasty, great-granddaughter of Emperor Sigismund and by marriage Margravine of Brandenburg-Ansbach and Brandenburg-Kulmbach.

Born in Kraków, she was the second daughter of Grand Duke of Lithuania and King Casimir IV of Poland and his wife Archduchess Elisabeth of Austria, daughter of the German king Albrecht. She was named after her paternal grandmother, Sophia of Halshany, Queen of Poland.

Sophia was baptised by John Gruszczynski, Bishop of Kraków. There is no information available concerning Sophia's upbringing or education.